P2.03b-068 The Druggable Mutation Landscape of Lung Adenocarcinoma

Druggable oncogene fusions in invasive mucinous lung adenocarcinoma.

PURPOSE To identify druggable oncogenic fusions in invasive mucinous adenocarcinoma (IMA) of the lung, a malignant type of lung adenocarcinoma in which KRAS mutations frequently occur. EXPERIMENTAL DESIGN From an IMA cohort of 90 cases, consisting of 56 cases (62%) with KRAS mutations and 34 cases without (38%), we conducted whole-transcriptome sequencing of 32 IMAs, including 27 cases withou...

Epidermal Growth Factor Receptor (EGFR) Gene Mutation Analysis in Adenocarcinoma of Lung, the First Report from Iran

Background and Objective: Epidermal growth factor receptor (EGFR) gene mutation, especially in exons 18 to 21, is an important predictor of the response rate of lung adenocarcinoma to tyrosine kinase inhibitors. There are variable reports from Asian and European countries, as well as North America, about the frequency of the EGFR mutation in lung adenocarcinoma, yet molecular s...

the role of rnasel mutation in the complex genetic landscape of prostate adenocarcinoma

The transcriptional landscape and mutational profile of lung adenocarcinoma.

All cancers harbor molecular alterations in their genomes. The transcriptional consequences of these somatic mutations have not yet been comprehensively explored in lung cancer. Here we present the first large scale RNA sequencing study of lung adenocarcinoma, demonstrating its power to identify somatic point mutations as well as transcriptional variants such as gene fusions, alternative splici...

Druggable Drivers of Lung Cancer

Cancer genomic sequencing is ushering in an era of targeted and personalized therapeutic approaches for the treatment of cancer. Targeted therapies are yielding impressive response rates in patients, leading to longer progression-free survival and less severe side effects than those associated with traditional chemotherapeutic regimens. Treatment of EGFR mutation-positive lung cancer patients w...